Watch: Cowboys QB Dak Prescott stars in hilarious, important PSA

The topic is personal for Prescott, as he lost his mother to colon cancer.

He joins actor Ryan Reynolds and his creative agency (Maximum Effort) in teaming up for Lead From Behind, which is a "series of unique and creative videos featuring celebrities in sports and entertainment spreading awareness that colon cancer is The Preventable Cancer and that there are a variety of screening options."

Just because Prescott is discussing an important topic during the PSA didn't mean he couldn't have fun with it.

He starts by highlighting some of the "s--t" he takes from fans as a professional quarterback. Prescott then goes over the process of getting screened for colon cancer and if you end up using a home screening kit the joy of placing a sticker of "something you want to s--t on" on the sample collection container.

A number of images then pop up on the screen, clearly alluding to some of the other NFL teams (Bears, Cardinals, Lions etc.), plus a referee.

"Not a fan of marine life? Slap it on," Prescott said, showing a picture of a Dolphin. "Have issues with old-timey prospectors? Boom. It works with anything."

One of the most notable stickers that the two-time Pro Bowler shows off is a "large American predatory bird," clearly showing an eagle and hinting at the rival Philadelphia Eagles.

Prescott and the Cowboys host the Eagles at 8:20 p.m. ET on "Sunday Night Football" in Week 14. Expect a lot of s--t talking from Philly fans leading up to the big NFC East clash.